ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

ATF2

Function : activating transcription factor 2
Description : This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

Classification  

Super Class Basic domains
Class Basic leucine zipper factors (bZIP)
Family Jun-related factors
Sub Family ATF-2-like factors

External references

Ensembl ENSG00000115966
RefSeq NP_001243019
Uniprot P15336
Aliases CRE-BP1, CREB-2, CREB2, HB16, TREB7
UCSC Gene coordinates chr2:175072249-175168205

External Links

JASPAR ATF2
Wikipedia ATF2
WikiGenes ATF2
Transcription Factor Encylopedia ATF2
GeneCards ATF2
FactorBook ATF2


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for ATF2

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for ATF2