ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

ATF4

Function : activating transcription factor 4
Description : This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

Classification  

Super Class Basic domains
Class Basic leucine zipper factors (bZIP)
Family ATF-4-related factors
Sub Family None

External references

Ensembl ENSG00000128272
RefSeq NP_001666
Uniprot P18848
Aliases CREB-2, CREB2, TAXREB67, TXREB
UCSC Gene coordinates chr22:39519708-39522685

External Links

JASPAR MA0833.1
Wikipedia ATF4
WikiGenes ATF4
Transcription Factor Encylopedia ATF4
GeneCards ATF4
FactorBook ATF4


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for ATF4

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for ATF4