ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

ATRX

Function : ATRX, chromatin remodeler
Description : The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]

Classification  

Super Class Zinc-coordinating DNA-binding domains
Class Other C4 zinc finger-type factors
Family GATA-type zinc fingers
Sub Family Single GATA-type zinc-finger

External references

Ensembl ENSG00000085224
RefSeq NP_000480
Uniprot P46100
Aliases JMS, MRX52, RAD54, RAD54L, XH2, XNP, ZNF-HX
UCSC Gene coordinates chrX:77504877-77786268

External Links

JASPAR ATRX
Wikipedia ATRX
WikiGenes ATRX
Transcription Factor Encylopedia ATRX    
GeneCards ATRX
FactorBook ATRX


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for ATRX

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for ATRX