ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

CBFA2T2

Function : CBFA2/RUNX1 translocation partner 2
Description : In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]

Classification  

Super Class Unknown
Class Unknown
Family Unknown
Sub Family Unknown

External references

Ensembl ENSG00000078699
RefSeq NP_001028171
Uniprot O43439
Aliases EHT, MTGR1, ZMYND3, p85
UCSC Gene coordinates chr20:33490067-33650030

External Links

JASPAR CBFA2T2
Wikipedia CBFA2T2
WikiGenes CBFA2T2
Transcription Factor Encylopedia CBFA2T2    
GeneCards CBFA2T2
FactorBook CBFA2T2


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for CBFA2T2

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for CBFA2T2