ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

CIITA

Function : class II major histocompatibility complex transactivator
Description : This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Classification  

Super Class Unknown
Class Unknown
Family Unknown
Sub Family Unknown

External references

Ensembl ENSG00000179583
RefSeq NP_000237
Uniprot P33076
Aliases C2TA, CIITAIV, MHC2TA, NLRA
UCSC Gene coordinates chr16:10866207-10941561

External Links

JASPAR CIITA
Wikipedia CIITA
WikiGenes CIITA
Transcription Factor Encylopedia CIITA    
GeneCards CIITA
FactorBook CIITA


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for CIITA

MACS - Datasets excluded for CIITA

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for CIITA