ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

CLOCK

Function : clock circadian regulator
Description : The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Classification  

Super Class Basic domains
Class Basic helix-loop-helix factors (bHLH)
Family PAS domain factors
Sub Family Arnt-like factors

External references

Ensembl ENSG00000134852
RefSeq NP_004889
Uniprot O15516
Aliases KAT13D, bHLHe8
UCSC Gene coordinates chr4:55427900-55547137

External Links

JASPAR MA0819.1
Wikipedia CLOCK
WikiGenes CLOCK
Transcription Factor Encylopedia CLOCK
GeneCards CLOCK
FactorBook CLOCK


Genomic visualization & Analyses for MACS

Datasets
quality 		DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)		 BED file
Peak sequences FASTA file

MACS - Datasets retained for CLOCK

MACS - Datasets excluded for CLOCK

Genomic visualization & Analyses for JAMM

Datasets
quality 		DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)		 BED file
Peak sequences FASTA file

JAMM - Datasets retained for CLOCK