ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

DNMT3B

Function : DNA methyltransferase 3 beta
Description : CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]

Classification  

Super Class Zinc-coordinating DNA-binding domains
Class Other C4 zinc finger-type factors
Family GATA-type zinc fingers
Sub Family Single GATA-type zinc-finger

External references

Ensembl ENSG00000088305
RefSeq NP_008823
Uniprot Q9UBC3
Aliases ICF, ICF1, M.HsaIIIB
UCSC Gene coordinates chr20:32762384-32809355

External Links

JASPAR DNMT3B
Wikipedia DNMT3B
WikiGenes DNMT3B
Transcription Factor Encylopedia DNMT3B    
GeneCards DNMT3B
FactorBook DNMT3B


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for DNMT3B

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for DNMT3B