ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

DUX4

Function : double homeobox 4
Description : This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Classification  

Super Class Helix-turn-helix domains
Class Homeo domain factors
Family Paired-related HD factors
Sub Family DUX

External references

Ensembl ENSG00000260596
RefSeq NP_001280727
Uniprot Q9UBX2
Aliases DUX4L
UCSC Gene coordinates chr4:190173700-190175844

External Links

JASPAR MA0468.1
Wikipedia DUX4
WikiGenes DUX4
Transcription Factor Encylopedia DUX4    
GeneCards DUX4
FactorBook DUX4


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for DUX4

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for DUX4