ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

E2F1

Function : E2F transcription factor 1
Description : The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

Classification  

Super Class Helix-turn-helix domains
Class Fork head / winged helix factors
Family E2F-related factors
Sub Family E2F

External references

Ensembl ENSG00000101412
RefSeq NP_005216
Uniprot Q01094
Aliases E2F-1, RBAP1, RBBP3, RBP3
UCSC Gene coordinates chr20:33675485-33686403

External Links

JASPAR MA0024.3
Wikipedia E2F1
WikiGenes E2F1
Transcription Factor Encylopedia E2F1
GeneCards E2F1
FactorBook E2F1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for E2F1

MACS - Datasets excluded for E2F1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for E2F1