ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

E2F4

Function : E2F transcription factor 4
Description : The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]

Classification  

Super Class Helix-turn-helix domains
Class Fork head / winged helix factors
Family E2F-related factors
Sub Family E2F

External references

Ensembl ENSG00000205250
RefSeq NP_001941
Uniprot Q16254
Aliases E2F-4
UCSC Gene coordinates chr16:67192164-67198917

External Links

JASPAR MA0470.1
Wikipedia E2F4
WikiGenes E2F4
Transcription Factor Encylopedia E2F4
GeneCards E2F4
FactorBook E2F4


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for E2F4

MACS - Datasets excluded for E2F4

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for E2F4