ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

E2F5

Function : E2F transcription factor 5
Description : The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Classification  

Super Class Helix-turn-helix domains
Class Fork head / winged helix factors
Family E2F-related factors
Sub Family E2F

External references

Ensembl ENSG00000133740
RefSeq NP_001077057
Uniprot Q15329
Aliases E2F-5
UCSC Gene coordinates chr8:85177383-85214517

External Links

JASPAR E2F5
Wikipedia E2F5
WikiGenes E2F5
Transcription Factor Encylopedia E2F5
GeneCards E2F5
FactorBook E2F5


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for E2F5

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for E2F5