ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

ERG

Function : ERG, ETS transcription factor
Description : This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]

Classification  

Super Class Helix-turn-helix domains
Class Tryptophan cluster factors
Family Ets-related factors
Sub Family Ets-like factors

External references

Ensembl ENSG00000157554
RefSeq NP_001317954
Uniprot P11308
Aliases erg-3, p55
UCSC Gene coordinates chr21:38367260-38662044

External Links

JASPAR MA0474.2
Wikipedia ERG
WikiGenes ERG
Transcription Factor Encylopedia ERG    
GeneCards ERG
FactorBook ERG


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for ERG

MACS - Datasets excluded for ERG

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for ERG