ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

ESR1

Function : estrogen receptor 1
Description : This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]

Classification  

Super Class Zinc-coordinating DNA-binding domains
Class Nuclear receptors with C4 zinc fingers
Family Steroid hormone receptors (NR3)
Sub Family ER-like receptors (NR3A&B)

External references

Ensembl ENSG00000091831
RefSeq NP_001278159
Uniprot P03372
Aliases ER, ESR, ESRA, ESTRR, Era, NR3A1
UCSC Gene coordinates chr6:151654147-152103273

External Links

JASPAR MA0112.3
Wikipedia ESR1
WikiGenes ESR1
Transcription Factor Encylopedia ESR1
GeneCards ESR1
FactorBook ESR1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for ESR1

MACS - Datasets excluded for ESR1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for ESR1