Function : Fli-1 proto-oncogene, ETS transcription factor
Description : This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
| Super Class | Helix-turn-helix domains |
| Class | Tryptophan cluster factors |
| Family | Ets-related factors |
| Sub Family | Ets-like factors |
| Ensembl | ENSG00000151702 |
| RefSeq | NP_002008 |
| Uniprot | Q01543 |
| Aliases | BDPLT21, EWSR2, SIC-1 |
| UCSC Gene coordinates | chr11:128685262-128813266 |
| JASPAR | MA0475.2 |
| Wikipedia | FLI1 |
| WikiGenes | FLI1 |
| Transcription Factor Encylopedia | FLI1 |
| GeneCards | FLI1 |
| FactorBook | FLI1 |
| Datasets quality |
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DNA constraint | Motifs | |
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UCSC genome browser |
| All peaks | BED file | ![]() |
| Merged peaks (non-redundant peaks) |
BED file | ![]() |
| Peak sequences | FASTA file |
| Datasets quality |
|
|
DNA constraint | Motifs | |
|
UCSC genome browser |
| All peaks | BED file | ![]() |
| Merged peaks (non-redundant peaks) |
BED file | ![]() |
| Peak sequences | FASTA file |