ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

FOXP2

Function : forkhead box P2
Description : This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Classification  

Super Class Helix-turn-helix domains
Class Fork head / winged helix factors
Family Forkhead box (FOX) factors
Sub Family FOXP

External references

Ensembl ENSG00000128573
RefSeq NP_001166237
Uniprot O15409
Aliases CAGH44, SPCH1, TNRC10
UCSC Gene coordinates chr7:114086309-114693771

External Links

JASPAR MA0593.1
Wikipedia FOXP2
WikiGenes FOXP2
Transcription Factor Encylopedia FOXP2
GeneCards FOXP2
FactorBook FOXP2


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for FOXP2

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for FOXP2