ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

HIF1A

Function : hypoxia inducible factor 1 alpha subunit
Description : This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

Classification  

Super Class Basic domains
Class Basic helix-loop-helix factors (bHLH)
Family PAS domain factors
Sub Family Ahr-like factors

External references

Ensembl ENSG00000100644
RefSeq NP_001521
Uniprot Q16665
Aliases HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
UCSC Gene coordinates chr14:61695400-61748258

External Links

JASPAR MA1106.1
Wikipedia HIF1A
WikiGenes HIF1A
Transcription Factor Encylopedia HIF1A
GeneCards HIF1A
FactorBook HIF1A


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for HIF1A

MACS - Datasets excluded for HIF1A

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for HIF1A