ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

IRF1

Function : interferon regulatory factor 1
Description : The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]

Classification  

Super Class Helix-turn-helix domains
Class Tryptophan cluster factors
Family Interferon-regulatory factors
Sub Family None

External references

Ensembl ENSG00000125347
RefSeq NP_002189
Uniprot P10914
Aliases IRF-1, MAR
UCSC Gene coordinates chr5:132481608-132490788

External Links

JASPAR MA0050.2
Wikipedia IRF1
WikiGenes IRF1
Transcription Factor Encylopedia IRF1
GeneCards IRF1
FactorBook IRF1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for IRF1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for IRF1