ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

IRF4

Function : interferon regulatory factor 4
Description : The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

Classification  

Super Class Helix-turn-helix domains
Class Tryptophan cluster factors
Family Interferon-regulatory factors
Sub Family None

External references

Ensembl ENSG00000137265
RefSeq NP_001182215
Uniprot Q15306
Aliases LSIRF, MUM1, NF-EM5, SHEP8
UCSC Gene coordinates chr6:391738-411442

External Links

JASPAR MA1419.1
Wikipedia IRF4
WikiGenes IRF4
Transcription Factor Encylopedia IRF4    
GeneCards IRF4
FactorBook IRF4


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for IRF4

MACS - Datasets excluded for IRF4

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for IRF4