ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

KMT2A

Function : lysine methyltransferase 2A
Description : This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

Classification  

Super Class Zinc-coordinating DNA-binding domains
Class CXXC zinc finger factors
Family CpG-binding proteins
Sub Family None

External references

Ensembl ENSG00000118058
RefSeq NP_001184033
Uniprot Q03164
Aliases ALL-1, CXXC7, HRX, HTRX1, MLL, MLL1, MLL1A, TRX1, WDSTS
UCSC Gene coordinates chr11:118436489-118526831

External Links

JASPAR KMT2A
Wikipedia KMT2A
WikiGenes KMT2A
Transcription Factor Encylopedia KMT2A    
GeneCards KMT2A
FactorBook KMT2A


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for KMT2A

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for KMT2A