ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

LEF1

Function : lymphoid enhancer binding factor 1
Description : This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Classification  

Super Class Other all-alpha-helical DNA-binding domains
Class High-mobility group (HMG) domain factors
Family TCF-7-related factors
Sub Family None

External references

Ensembl ENSG00000138795
RefSeq NP_057353
Uniprot Q9UJU2
Aliases LEF-1, TCF10, TCF1ALPHA, TCF7L3
UCSC Gene coordinates chr4:108047544-108168955

External Links

JASPAR MA0768.1
Wikipedia LEF1
WikiGenes LEF1
Transcription Factor Encylopedia LEF1
GeneCards LEF1
FactorBook LEF1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for LEF1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for LEF1