ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

MAFK

Function : MAF bZIP transcription factor K
Description : The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008]

Classification  

Super Class Basic domains
Class Basic leucine zipper factors (bZIP)
Family Maf-related factors
Sub Family Small Maf factors

External references

Ensembl ENSG00000198517
RefSeq NP_002351
Uniprot O60675
Aliases NFE2U, P18
UCSC Gene coordinates chr7:1530731-1543042

External Links

JASPAR MA0496.2
Wikipedia MAFK
WikiGenes MAFK
Transcription Factor Encylopedia MAFK
GeneCards MAFK
FactorBook MAFK


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for MAFK

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for MAFK