ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

MBD1

Function : methyl-CpG binding domain protein 1
Description : The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]

Classification  

Super Class Zinc-coordinating DNA-binding domains
Class CXXC zinc finger factors
Family CpG-binding proteins
Sub Family None

External references

Ensembl ENSG00000141644
RefSeq NP_001191070
Uniprot Q9UIS9
Aliases CXXC3, PCM1, RFT
UCSC Gene coordinates chr18:50266881-50281773

External Links

JASPAR MBD1
Wikipedia MBD1
WikiGenes MBD1
Transcription Factor Encylopedia MBD1    
GeneCards MBD1
FactorBook MBD1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for MBD1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for MBD1