ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

MDM2

Function : MDM2 proto-oncogene
Description : This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

Classification  

Super Class Unknown
Class Unknown
Family Unknown
Sub Family Unknown

External references

Ensembl ENSG00000135679
RefSeq NP_002383
Uniprot Q00987
Aliases ACTFS, HDMX, hdm2
UCSC Gene coordinates chr12:68808148-68845543

External Links

JASPAR MDM2
Wikipedia MDM2
WikiGenes MDM2
Transcription Factor Encylopedia MDM2    
GeneCards MDM2
FactorBook MDM2


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for MDM2

MACS - Datasets excluded for MDM2

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for MDM2