ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

MTA1

Function : metastasis associated 1
Description : This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Classification  

Super Class Zinc-coordinating DNA-binding domains, Helix-turn-helix domains
Class Other C4 zinc finger-type factors, Tryptophan cluster factors
Family GATA-type zinc fingers, Myb/SANT domain factors
Sub Family Single GATA-type zinc-finger, MIER-like factors

External references

Ensembl ENSG00000182979
RefSeq NP_004680
Uniprot Q13330
Aliases -
UCSC Gene coordinates chr14:105419848-105470728

External Links

JASPAR MTA1
Wikipedia MTA1
WikiGenes MTA1
Transcription Factor Encylopedia MTA1    
GeneCards MTA1
FactorBook MTA1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for MTA1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for MTA1