ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

MTA2

Function : metastasis associated 1 family member 2
Description : This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

Classification  

Super Class Zinc-coordinating DNA-binding domains, Helix-turn-helix domains
Class Other C4 zinc finger-type factors, Tryptophan cluster factors
Family GATA-type zinc fingers, Myb/SANT domain factors
Sub Family Single GATA-type zinc-finger, MIER-like factors

External references

Ensembl ENSG00000149480
RefSeq NP_004730
Uniprot O94776
Aliases MTA1L1, PID
UCSC Gene coordinates chr11:62593202-62601839

External Links

JASPAR MTA2
Wikipedia MTA2
WikiGenes MTA2
Transcription Factor Encylopedia MTA2    
GeneCards MTA2
FactorBook MTA2


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for MTA2

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for MTA2