ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

MXI1

Function : MAX interactor 1, dimerization protein
Description : Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

Classification  

Super Class Basic domains
Class Basic helix-loop-helix factors (bHLH)
Family bHLH-ZIP factors
Sub Family Mad-like factors

External references

Ensembl ENSG00000119950
RefSeq NP_569157
Uniprot P50539
Aliases MAD2, MXD2, MXI, bHLHc11
UCSC Gene coordinates chr10:110207604-110287364

External Links

JASPAR MA1108.1
Wikipedia MXI1
WikiGenes MXI1
Transcription Factor Encylopedia MXI1    
GeneCards MXI1
FactorBook MXI1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for MXI1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for MXI1