ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

MYC

Function : MYC proto-oncogene, bHLH transcription factor
Description : This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

Classification  

Super Class Basic domains
Class Basic helix-loop-helix factors (bHLH)
Family bHLH-ZIP factors
Sub Family Myc / Max factors

External references

Ensembl ENSG00000136997
RefSeq NP_002458
Uniprot P01106
Aliases MRTL, MYCC, bHLHe39, c-Myc
UCSC Gene coordinates chr8:127736068-127741433

External Links

JASPAR MA0147.3
Wikipedia MYC
WikiGenes MYC
Transcription Factor Encylopedia MYC    
GeneCards MYC
FactorBook MYC


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for MYC

MACS - Datasets excluded for MYC

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for MYC