ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

NCOA2

Function : nuclear receptor coactivator 2
Description : The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Classification  

Super Class Basic domains
Class Basic helix-loop-helix factors (bHLH)
Family PAS domain factors
Sub Family NCoA factors

External references

Ensembl ENSG00000140396
RefSeq NP_001308642
Uniprot Q15596
Aliases GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75
UCSC Gene coordinates chr8:70109761-70405389

External Links

JASPAR NCOA2
Wikipedia NCOA2
WikiGenes NCOA2
Transcription Factor Encylopedia NCOA2    
GeneCards NCOA2
FactorBook NCOA2


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for NCOA2

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for NCOA2