ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

NFKB1

Function : nuclear factor kappa B subunit 1
Description : This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]

Classification  

Super Class Immunoglobulin fold
Class Rel homology region (RHR) factors
Family NF-kappaB-related factors
Sub Family NF-kappaB p50 subunit-like factors

External references

Ensembl ENSG00000109320
RefSeq NP_003989
Uniprot P19838
Aliases CVID12, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50
UCSC Gene coordinates chr4:102501328-102617301

External Links

JASPAR MA0105.4
Wikipedia NFKB1
WikiGenes NFKB1
Transcription Factor Encylopedia NFKB1    
GeneCards NFKB1
FactorBook NFKB1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for NFKB1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for NFKB1