ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

NKX2-1

Function : homeobox protein Nkx-2.1
Description : NKX2-1 This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]

Classification  

Super Class Helix-turn-helix domains
Class Homeo domain factors
Family NK-related factors
Sub Family NK-2.1

External references

Ensembl ENSG00000136352
RefSeq NP_001073136.1
Uniprot P43699
Aliases BCH, BHC, NK-2, NKX2.1, NKX2A, NMTC1, T/EBP, TEBP, TITF1, TTF-1, TTF1
UCSC Gene coordinates

External Links

JASPAR NKX2-1
Wikipedia NKX2-1
WikiGenes NKX2-1
Transcription Factor Encylopedia NKX2-1
GeneCards NKX2-1
FactorBook NKX2-1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for NKX2-1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for NKX2-1