ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

NR1H2

Function : nuclear receptor subfamily 1 group H member 2
Description : The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]

Classification  

Super Class Zinc-coordinating DNA-binding domains
Class Nuclear receptors with C4 zinc fingers
Family Thyroid hormone receptor-related factors (NR1)
Sub Family LXR (NR1H)

External references

Ensembl ENSG00000131408
RefSeq NP_001243576
Uniprot P55055
Aliases LXR-b, LXRB, NER, NER-I, RIP15, UNR
UCSC Gene coordinates chr19:50376422-50383027

External Links

JASPAR MA0115.1
Wikipedia NR1H2
WikiGenes NR1H2
Transcription Factor Encylopedia NR1H2
GeneCards NR1H2
FactorBook NR1H2


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for NR1H2

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for NR1H2