ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

NR1H3

Function : nuclear receptor subfamily 1 group H member 3
Description : The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Classification  

Super Class Zinc-coordinating DNA-binding domains
Class Nuclear receptors with C4 zinc fingers
Family Thyroid hormone receptor-related factors (NR1)
Sub Family LXR (NR1H)

External references

Ensembl ENSG00000025434
RefSeq NP_001123574
Uniprot Q13133
Aliases LXR-a, LXRA, RLD-1
UCSC Gene coordinates chr11:47248299-47269032

External Links

JASPAR MA0494.1
Wikipedia NR1H3
WikiGenes NR1H3
Transcription Factor Encylopedia NR1H3
GeneCards NR1H3
FactorBook NR1H3


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for NR1H3

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for NR1H3