ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

NR3C1

Function : nuclear receptor subfamily 3 group C member 1
Description : This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

Classification  

Super Class Zinc-coordinating DNA-binding domains
Class Nuclear receptors with C4 zinc fingers
Family Steroid hormone receptors (NR3)
Sub Family GR-like receptors (NR3C)

External references

Ensembl ENSG00000113580
RefSeq NP_001191187
Uniprot P04150
Aliases GCCR, GCR, GCRST, GR, GRL
UCSC Gene coordinates chr5:143277930-143435511

External Links

JASPAR MA0113.3
Wikipedia NR3C1
WikiGenes NR3C1
Transcription Factor Encylopedia NR3C1
GeneCards NR3C1
FactorBook NR3C1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for NR3C1

MACS - Datasets excluded for NR3C1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for NR3C1