ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

NSD2

Function : nuclear receptor binding SET domain protein 2
Description : This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008]

Classification  

Super Class Other all-alpha-helical DNA-binding domains
Class High-mobility group (HMG) domain factors
Family WHSC1-related factors
Sub Family None

External references

Ensembl ENSG00000109685
RefSeq NP_001035889
Uniprot O96028
Aliases KMT3F, KMT3G, MMSET, REIIBP, TRX5, WHS, WHSC1
UCSC Gene coordinates chr4:1871356-1982206

External Links

JASPAR NSD2
Wikipedia NSD2
WikiGenes NSD2
Transcription Factor Encylopedia NSD2    
GeneCards NSD2
FactorBook NSD2


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for NSD2

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for NSD2