ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

OTX2

Function : orthodenticle homeobox 2
Description : This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012]

Classification  

Super Class Helix-turn-helix domains
Class Homeo domain factors
Family Paired-related HD factors
Sub Family OTX

External references

Ensembl ENSG00000165588
RefSeq NP_001257452
Uniprot P32243
Aliases CPHD6, MCOPS5
UCSC Gene coordinates chr14:56800706-56810475

External Links

JASPAR MA0712.1
Wikipedia OTX2
WikiGenes OTX2
Transcription Factor Encylopedia OTX2    
GeneCards OTX2
FactorBook OTX2


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for OTX2

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for OTX2