ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

PAX5

Function : paired box 5
Description : This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Classification  

Super Class Helix-turn-helix domains
Class Paired box factors
Family Paired domain only
Sub Family PAX-2-like factors (partial homeobox)

External references

Ensembl ENSG00000196092
RefSeq NP_057953
Uniprot Q02548
Aliases ALL3, BSAP
UCSC Gene coordinates chr9:36833273-37035948

External Links

JASPAR MA0014.3
Wikipedia PAX5
WikiGenes PAX5
Transcription Factor Encylopedia PAX5    
GeneCards PAX5
FactorBook PAX5


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for PAX5

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for PAX5