ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

POU5F1

Function : POU class 5 homeobox 1
Description : This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]

Classification  

Super Class Helix-turn-helix domains
Class Homeo domain factors
Family POU domain factors
Sub Family POU5 (Oct-3/4-like factors)

External references

Ensembl ENSG00000235068
RefSeq NP_002692
Uniprot Q01860
Aliases OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4
UCSC Gene coordinates chr6:31164336-31170692

External Links

JASPAR MA1115.1
Wikipedia POU5F1
WikiGenes POU5F1
Transcription Factor Encylopedia POU5F1    
GeneCards POU5F1
FactorBook POU5F1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for POU5F1

MACS - Datasets excluded for POU5F1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for POU5F1