ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

PTRF

Function : polymerase I and transcript release factor
Description : This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]

Classification  

Super Class Unknown
Class Unknown
Family Unknown
Sub Family Unknown

External references

Ensembl ENSG00000177469
RefSeq NP_036364
Uniprot Q6NZI2
Aliases CAVIN1 , CAVIN, CGL4, FKSG13, PTRF, cavin-1
UCSC Gene coordinates chr17:42402449-42423320

External Links

JASPAR PTRF
Wikipedia PTRF
WikiGenes PTRF
Transcription Factor Encylopedia PTRF    
GeneCards PTRF
FactorBook PTRF


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for PTRF

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for PTRF