ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

RUNX2

Function : runt related transcription factor 2
Description : This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]

Classification  

Super Class Immunoglobulin fold
Class Runt domain factors
Family Runt-related factors
Sub Family None

External references

Ensembl ENSG00000124813
RefSeq NP_001019801
Uniprot Q13950
Aliases AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA
UCSC Gene coordinates chr6:45328141-45664031

External Links

JASPAR MA0511.2
Wikipedia RUNX2
WikiGenes RUNX2
Transcription Factor Encylopedia RUNX2    
GeneCards RUNX2
FactorBook RUNX2


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for RUNX2

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for RUNX2