ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

SMAD1

Function : SMAD family member 1
Description : The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Classification  

Super Class beta-Hairpin exposed by an alpha/beta-scaffold
Class SMAD/NF-1 DNA-binding domain factors
Family SMAD factors
Sub Family Regulatory Smads (R-Smad)

External references

Ensembl ENSG00000170365
RefSeq NP_005891
Uniprot Q15797
Aliases BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1
UCSC Gene coordinates chr4:145481305-145559175

External Links

JASPAR SMAD1
Wikipedia SMAD1
WikiGenes SMAD1
Transcription Factor Encylopedia SMAD1    
GeneCards SMAD1
FactorBook SMAD1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for SMAD1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for SMAD1