ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

SMAD4

Function : SMAD family member 4
Description : This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]

Classification  

Super Class beta-Hairpin exposed by an alpha/beta-scaffold
Class SMAD/NF-1 DNA-binding domain factors
Family SMAD factors
Sub Family Co-activating Smads (Co-Smad)

External references

Ensembl ENSG00000141646
RefSeq NP_005350
Uniprot Q13485
Aliases DPC4, JIP, MADH4, MYHRS
UCSC Gene coordinates chr18:51030212-51085041

External Links

JASPAR MA1153.1
Wikipedia SMAD4
WikiGenes SMAD4
Transcription Factor Encylopedia SMAD4    
GeneCards SMAD4
FactorBook SMAD4


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for SMAD4

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for SMAD4