ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

SREBF1

Function : sterol regulatory element binding transcription factor 1
Description : This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Mar 2016]

Classification  

Super Class Basic domains
Class Basic helix-loop-helix factors (bHLH)
Family bHLH-ZIP factors
Sub Family SREBP factors

External references

Ensembl ENSG00000072310
RefSeq NP_001308025
Uniprot P36956
Aliases SREBP1, bHLHd1
UCSC Gene coordinates chr17:17811348-17837016

External Links

JASPAR MA0829.1 MA0595.1
Wikipedia SREBF1
WikiGenes SREBF1
Transcription Factor Encylopedia SREBF1    
GeneCards SREBF1
FactorBook SREBF1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for SREBF1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for SREBF1