ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

SSRP1

Function : structure specific recognition protein 1
Description : The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]

Classification  

Super Class Other all-alpha-helical DNA-binding domains
Class High-mobility group (HMG) domain factors
Family WHSC1-related factors
Sub Family None

External references

Ensembl ENSG00000149136
RefSeq NP_003137
Uniprot Q08945
Aliases FACT, FACT80, T160
UCSC Gene coordinates chr11:57325984-57335876

External Links

JASPAR SSRP1
Wikipedia SSRP1
WikiGenes SSRP1
Transcription Factor Encylopedia SSRP1    
GeneCards SSRP1
FactorBook SSRP1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for SSRP1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for SSRP1