ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

STAT2

Function : signal transducer and activator of transcription 2
Description : The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Classification  

Super Class Immunoglobulin fold
Class STAT domain factors
Family STAT factors
Sub Family None

External references

Ensembl ENSG00000170581
RefSeq NP_005410
Uniprot P52630
Aliases IMD44, ISGF-3, P113, STAT113
UCSC Gene coordinates chr12:56341596-56360252

External Links

JASPAR MA0517.1
Wikipedia STAT2
WikiGenes STAT2
Transcription Factor Encylopedia STAT2    
GeneCards STAT2
FactorBook STAT2


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for STAT2

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for STAT2