ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

STAT3

Function : signal transducer and activator of transcription 3
Description : The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

Classification  

Super Class Immunoglobulin fold
Class STAT domain factors
Family STAT factors
Sub Family None

External references

Ensembl ENSG00000168610
RefSeq NP_003141
Uniprot P40763
Aliases ADMIO, ADMIO1, APRF, HIES
UCSC Gene coordinates chr17:42313323-42388504

External Links

JASPAR MA0144.2
Wikipedia STAT3
WikiGenes STAT3
Transcription Factor Encylopedia STAT3
GeneCards STAT3
FactorBook STAT3


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for STAT3

MACS - Datasets excluded for STAT3

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for STAT3