ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

STAT5A

Function : signal transducer and activator of transcription 5A
Description : The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Classification  

Super Class Immunoglobulin fold
Class STAT domain factors
Family STAT factors
Sub Family None

External references

Ensembl ENSG00000126561
RefSeq NP_003143
Uniprot P42229
Aliases MGF, STAT5
UCSC Gene coordinates chr17:42287546-42311942

External Links

JASPAR MA0519.1
Wikipedia STAT5A
WikiGenes STAT5A
Transcription Factor Encylopedia STAT5A
GeneCards STAT5A
FactorBook STAT5A


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for STAT5A

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for STAT5A