ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

STAT5B

Function : signal transducer and activator of transcription 5B
Description : The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

Classification  

Super Class Immunoglobulin fold
Class STAT domain factors
Family STAT factors
Sub Family None

External references

Ensembl ENSG00000173757
RefSeq NP_036580
Uniprot P51692
Aliases STAT5
UCSC Gene coordinates chr17:42199176-42276459

External Links

JASPAR STAT5B
Wikipedia STAT5B
WikiGenes STAT5B
Transcription Factor Encylopedia STAT5B
GeneCards STAT5B
FactorBook STAT5B


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for STAT5B

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for STAT5B