ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

TBX21

Function : T-box 21
Description : This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

Classification  

Super Class Immunoglobulin fold
Class T-Box factors
Family TBrain-related factors
Sub Family None

External references

Ensembl ENSG00000073861
RefSeq NP_037483
Uniprot Q9UL17
Aliases T-PET, T-bet, TBET, TBLYM
UCSC Gene coordinates chr17:47733239-47746121

External Links

JASPAR MA0690.1
Wikipedia TBX21
WikiGenes TBX21
Transcription Factor Encylopedia TBX21
GeneCards TBX21
FactorBook TBX21


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for TBX21

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for TBX21