ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

TCF3

Function : transcription factor 3
Description : This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

Classification  

Super Class Basic domains
Class Basic helix-loop-helix factors (bHLH)
Family E2A-related factors
Sub Family None

External references

Ensembl ENSG00000071564
RefSeq NP_001338707
Uniprot P15923
Aliases AGM8, E2A, E47, ITF1, TCF-3, VDIR, bHLHb21
UCSC Gene coordinates chr19:1609289-1652589

External Links

JASPAR MA0522.2
Wikipedia TCF3
WikiGenes TCF3
Transcription Factor Encylopedia TCF3    
GeneCards TCF3
FactorBook TCF3


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for TCF3

MACS - Datasets excluded for TCF3

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for TCF3