ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

TCF4

Function : transcription factor 4
Description : This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]

Classification  

Super Class Basic domains
Class Basic helix-loop-helix factors (bHLH)
Family E2A-related factors
Sub Family None

External references

Ensembl ENSG00000196628
RefSeq NP_001335148
Uniprot P15884
Aliases E2-2, FECD3, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4, bHLHb19
UCSC Gene coordinates chr18:55222330-55635992

External Links

JASPAR MA0830.1
Wikipedia TCF4
WikiGenes TCF4
Transcription Factor Encylopedia TCF4    
GeneCards TCF4
FactorBook TCF4


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for TCF4

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for TCF4